Assay Detail
Binding
CHEMBL820504
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Binding affinity against alpha-1 adrenergic receptor in rat cerebral cortex tissue using [3H]WB-4101 as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of the putative metabolites of the atypical antipsychotic agent tiospirone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.60 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114451 | — | — | 1 | 9.06 |
| CHEMBL115367 | — | — | 1 | 8.89 |
| CHEMBL115486 | — | — | 1 | 8.79 |
| CHEMBL321591 | — | — | 1 | 8.60 |
| CHEMBL114131 | — | — | 1 | 8.15 |
| CHEMBL326775 | — | — | 1 | 8.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114451 | — | IC50 | = | 0.876 | nM | 9.06 |
| CHEMBL115367 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL115486 | — | IC50 | = | 1.63 | nM | 8.79 |
| CHEMBL321591 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL114131 | — | IC50 | = | 7.15 | nM | 8.15 |
| CHEMBL326775 | — | IC50 | = | 8.3 | nM | 8.08 |