Assay Detail
Binding
CHEMBL820508
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Binding affinity towards alpha-1 adrenergic receptor
22
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.77 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.62 |
| CHEMBL1743783 | — | — | 1 | 7.54 |
| CHEMBL286849 | — | — | 2 | 7.52 |
| CHEMBL1743789 | — | — | 1 | 7.39 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 1 | 7.12 |
| CHEMBL35184 | — | — | 3 | 7.08 |
| CHEMBL287620 | — | — | 1 | 7.07 |
| CHEMBL1743799 | — | — | 1 | 7.06 |
| CHEMBL1743803 | — | — | 3 | 6.82 |
| CHEMBL34990 | — | — | 3 | 6.67 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 6.66 |
| CHEMBL1743785 | — | — | 1 | 6.60 |
| CHEMBL1743798 | — | — | 1 | 6.27 |
| CHEMBL1743819 | — | — | 1 | 6.17 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL1743783 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL286849 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL1743789 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL415 | CLOMIPRAMINE | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL35184 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL287620 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL1743799 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL1743803 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL1743803 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL35184 | — | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL286849 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL34990 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL11 | IMIPRAMINE | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL1743785 | — | Ki | = | 252.0 | nM | 6.60 |
| CHEMBL35184 | — | Ki | = | 262.0 | nM | 6.58 |
| CHEMBL34990 | — | Ki | = | 274.0 | nM | 6.56 |
| CHEMBL34990 | — | Ki | = | 314.0 | nM | 6.50 |
| CHEMBL1743798 | — | Ki | = | 536.0 | nM | 6.27 |
| CHEMBL1743803 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL1743819 | — | Ki | = | 675.0 | nM | 6.17 |
| CHEMBL41 | FLUOXETINE | Ki | = | 5260.0 | nM | 5.28 |