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Assay Detail

CHEMBL820576

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Functional
Inhibitory activity against L1210 leukemia cells
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Intermediate

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Correlations between cytotoxicity and topography of some 2-arylidenebenzocycloalkanones determined by X-ray crystallography.
Dimmock JR, Zello GA, Oloo EO, Quail JW, Kraatz HB, Perjési P, Aradi F, Takács-Novák K, Allen TM, Santos CL, Balzarini J, De Clercq E, Stables JP.
J Med Chem (2002) 45 : 3103 -3111
PubMed 12086496 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 43 4.51 5.67

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL852 MELPHALAN 4.0 1 5.67
CHEMBL322852 1 5.12
CHEMBL104235 1 5.10
CHEMBL104017 1 4.97
CHEMBL323526 1 4.91
CHEMBL322715 1 4.85
CHEMBL104440 1 4.64
CHEMBL323025 1 4.52
CHEMBL321588 1 4.52
CHEMBL321747 1 4.51
CHEMBL319863 1 4.48
CHEMBL104439 1 4.46
CHEMBL106940 1 4.45
CHEMBL105663 1 4.43
CHEMBL106340 1 4.42
CHEMBL323510 1 4.39
CHEMBL319931 1 4.38
CHEMBL104758 1 4.37
CHEMBL318170 1 4.35
CHEMBL320441 1 4.34
CHEMBL106856 1 4.34
CHEMBL320895 1 4.33
CHEMBL105195 1 4.30
CHEMBL105496 4-METHOXY CHALCONE 1 4.30
CHEMBL106771 1 4.23
CHEMBL319234 1 4.22
CHEMBL104728 1 4.21
CHEMBL104732 1 4.19
CHEMBL104073 1 4.19
CHEMBL106824 1 4.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL852 MELPHALAN IC50 = 2130.0 nM 5.67
CHEMBL322852 IC50 = 7610.0 nM 5.12
CHEMBL104235 IC50 = 7980.0 nM 5.10
CHEMBL104017 IC50 = 10800.0 nM 4.97
CHEMBL323526 IC50 = 12400.0 nM 4.91
CHEMBL322715 IC50 = 14000.0 nM 4.85
CHEMBL104440 IC50 = 22800.0 nM 4.64
CHEMBL323025 IC50 = 30400.0 nM 4.52
CHEMBL321588 IC50 = 30000.0 nM 4.52
CHEMBL321747 IC50 = 31200.0 nM 4.51
CHEMBL319863 IC50 = 33400.0 nM 4.48
CHEMBL104439 IC50 = 34400.0 nM 4.46
CHEMBL106940 IC50 = 35800.0 nM 4.45
CHEMBL105663 IC50 = 37000.0 nM 4.43
CHEMBL106340 IC50 = 38200.0 nM 4.42
CHEMBL323510 IC50 = 40500.0 nM 4.39
CHEMBL319931 IC50 = 42000.0 nM 4.38
CHEMBL104758 IC50 = 42300.0 nM 4.37
CHEMBL318170 IC50 = 45100.0 nM 4.35
CHEMBL320441 IC50 = 45700.0 nM 4.34
CHEMBL106856 IC50 = 46100.0 nM 4.34
CHEMBL320895 IC50 = 47000.0 nM 4.33
CHEMBL105496 4-METHOXY CHALCONE IC50 = 50400.0 nM 4.30
CHEMBL105195 IC50 = 50200.0 nM 4.30
CHEMBL106771 IC50 = 59100.0 nM 4.23
CHEMBL319234 IC50 = 60400.0 nM 4.22
CHEMBL104728 IC50 = 61200.0 nM 4.21
CHEMBL104732 IC50 = 64400.0 nM 4.19
CHEMBL104073 IC50 = 64200.0 nM 4.19
CHEMBL106824 IC50 = 82900.0 nM 4.08
CHEMBL320246 IC50 > 500000.0 nM -
CHEMBL106747 IC50 > 500000.0 nM -
CHEMBL107524 IC50 = 208000.0 nM -
CHEMBL105340 IC50 > 100000.0 nM -
CHEMBL323078 IC50 > 500000.0 nM -
CHEMBL104150 IC50 = 210000.0 nM -
CHEMBL107242 IC50 > 500000.0 nM -
CHEMBL107523 IC50 = 150000.0 nM -
CHEMBL104916 IC50 = 170000.0 nM -
CHEMBL107218 IC50 = 264000.0 nM -
CHEMBL107059 IC50 = 152000.0 nM -
CHEMBL105664 IC50 = 214000.0 nM -
CHEMBL106935 IC50 > 500000.0 nM -