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Compound Detail

CHEMBL323510

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COc1ccccc1/C=C1\CCc2ccccc2C1=O

Basic Information

ChEMBL ID CHEMBL323510
Phase Preclinical
Structure Type MOL
InChI Key FLTXETIZXYAOLF-NTCAYCPXSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
14
Publications
0
Known Names

Molecular Properties

264.3
MW (Da)
3.91
ALogP
2
HBA
0
HBD
26.3
PSA (Ų)
0.77
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H16O2
MW 264.32
Aromatic Rings 2
Heavy Atoms 20
NP-Likeness -0.43

Activity Summary

IC50 4 meas. best 4.9

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
CCRF-CEM
CHEMBL382
IC50 4.9 4.9 12600.0 1
P388
CHEMBL389
IC50 4.76 4.76 17500.0 1
NON-PROTEIN TARGET
CHEMBL3879801
IC50 4.5 4.5 31300.0 1
L1210
CHEMBL386
IC50 4.39 4.39 40500.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
35447343 10.1016/j.bmcl.2022.128743 Staphylococcus aureus 5
35447343 10.1016/j.bmcl.2022.128743 Molecular identity unknown 3
35447343 10.1016/j.bmcl.2022.128743 Escherichia coli 2
35447343 10.1016/j.bmcl.2022.128743 Salmonella typhimurium 2
35447343 10.1016/j.bmcl.2022.128743 Enterococcus faecalis 2
35447343 10.1016/j.bmcl.2022.128743 Unchecked 2
12086496 10.1021/jm010559p P388 1
12086496 10.1021/jm010559p L1210 1
12086496 10.1021/jm010559p NON-PROTEIN TARGET 1
12086496 10.1021/jm010559p CCRF-CEM 1
35447343 10.1016/j.bmcl.2022.128743 Pseudomonas aeruginosa 1
35447343 10.1016/j.bmcl.2022.128743 Candida albicans 1
35447343 10.1016/j.bmcl.2022.128743 Aspergillus fumigatus 1
35447343 10.1016/j.bmcl.2022.128743 Trichophyton rubrum 1

Data from ChEMBL 36 via Core Engine