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Target Snapshot

CHEMBL389 Target Snapshot

P388 · CELL-LINE · Mus musculus

9,798Compounds
4,875Assays
31Approved Drugs
4,523.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats P388 as ChEMBL target CHEMBL389. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
P388
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL389
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether P388 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelP388
UniProt AccessionN/A

P388

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as P388.

Review nameP388
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

31
Approved
7
Phase III
14
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC504,452.0
KI2.0
EC5069.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL256099 10.92 IC50 0.012 Preclinical
CHEMBL274951 10.74 IC50 0.018 Preclinical
CHEMBL255716 10.72 IC50 0.019 Preclinical
CHEMBL256302 10.52 IC50 0.03 Preclinical
CHEMBL1797231 10.49 IC50 0.032 Preclinical
CHEMBL257360 10.46 IC50 0.035 Preclinical
CHEMBL257572 10.4 IC50 0.04 Preclinical
CHEMBL3358841 10.4 IC50 0.04 Preclinical
CHEMBL1797230 10.31 IC50 0.0495 Preclinical
CHEMBL439714 10.15 IC50 0.07 Preclinical
Distribution

pChEMBL Value Distribution

409
5.0
327
5.5
298
6.0
329
6.5
232
7.0
225
7.5
146
8.0
86
8.5
38
9.0
13
9.5
pChEMBL
Approved Drugs

Approved Drugs

PLITIDEPSIN
CHEMBL451930
Approved 2018
TOPOTECAN
CHEMBL84
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
TRIMETREXATE
CHEMBL119
Approved 1993
PACLITAXEL
CHEMBL428647
Approved 1992
PODOFILOX
CHEMBL61
Approved 1990
MITOXANTRONE
CHEMBL58
Approved 1987
AMSACRINE
CHEMBL43
Approved 1987
ETOPOSIDE
CHEMBL44657
Approved 1983
MITOMYCIN
CHEMBL105
Approved 1981
DAUNORUBICIN HYDROCHLORIDE
CHEMBL1563
Approved 1979
DAUNORUBICIN
CHEMBL178
Approved 1979
DOXORUBICIN
CHEMBL53463
Approved 1974
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
Approved 1974
PLICAMYCIN
CHEMBL1237054
Approved 1970
CYTARABINE
CHEMBL803
Approved 1969
THIOGUANINE
CHEMBL727
Approved 1966
VINBLASTINE
CHEMBL159
Approved 1965
DACTINOMYCIN
CHEMBL1554
Approved 1964
MELPHALAN
CHEMBL852
Approved 1964
VINCRISTINE
CHEMBL90555
Approved 1963
FLUOROURACIL
CHEMBL185
Approved 1962
COLCHICINE
CHEMBL107
Approved 1961
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

5,004
Total Assays
2,136
Tested Compounds
3
Assay Types
Functional — 4,979 assays, 2,136 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 3,233 2 7.7
cell-based format 1,746 2,134 6.3
ADME — 24 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 14 0
cell-based format 10 4 5.4
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine