Review anchor
P388
CELL-LINE · Mus musculus
As of 2026-09-14
Evidence Snapshot
P388
CHEMBL389
CELL-LINE
Mus musculus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats P388 as ChEMBL target CHEMBL389. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL389
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-14
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why P388 matters
P388 is reviewed as P388; the current evidence base includes 31 approved drugs, 9798 compounds, and 4875 assays, with lead potency reaching pChEMBL 10.9.
Protein context
P388
P388
Review this target as P388.
Protein source · UniProt accession via ChEMBL component mappingDisease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 31 approved drugs, 9798 compounds, and 4875 assays for this target. The dominant activity type is IC50. CHEMBL256099 is the current potency anchor at pChEMBL 10.9.
Use CHEMBL256099 as the tractability anchor when discussing potency (pChEMBL 10.9).
Activity source · ChEMBL 36 via Core Engine
31 approved
pChEMBL 10.9
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why P388 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
9798
Total Compounds
4875
Total Assays
31
Approved Drugs
IC50: 4452.0, KI: 2.0, EC50: 69.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL256099
|
10.9 | IC50 | — |
|
|
No preferred name
CHEMBL274951
|
10.7 | IC50 | — |
|
|
No preferred name
CHEMBL255716
|
10.7 | IC50 | — |
|
|
No preferred name
CHEMBL256302
|
10.5 | IC50 | — |
|
|
No preferred name
CHEMBL1797231
|
10.5 | IC50 | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
PLITIDEPSIN
CHEMBL451930
|
2018 |
|
|
TOPOTECAN
CHEMBL84
|
1996 |
|
|
DOCETAXEL
CHEMBL3545252
|
1995 |
|
|
TRIMETREXATE
CHEMBL119
|
1993 |
|
|
PACLITAXEL
CHEMBL428647
|
1992 |
|
|
PODOFILOX
CHEMBL61
|
1990 |
|
|
MITOXANTRONE
CHEMBL58
|
1987 |
|
|
AMSACRINE
CHEMBL43
|
1987 |
|
|
ETOPOSIDE
CHEMBL44657
|
1983 |
|
|
MITOMYCIN
CHEMBL105
|
1981 |
|
|
DAUNORUBICIN HYDROCHLORIDE
CHEMBL1563
|
1979 |
|
|
DAUNORUBICIN
CHEMBL178
|
1979 |
|
|
DOXORUBICIN
CHEMBL53463
|
1974 |
|
|
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
|
1974 |
|
|
PLICAMYCIN
CHEMBL1237054
|
1970 |
|
|
CYTARABINE
CHEMBL803
|
1969 |
|
|
THIOGUANINE
CHEMBL727
|
1966 |
|
|
VINBLASTINE
CHEMBL159
|
1965 |
|
|
DACTINOMYCIN
CHEMBL1554
|
1964 |
|
|
MELPHALAN
CHEMBL852
|
1964 |
|
|
VINCRISTINE
CHEMBL90555
|
1963 |
|
|
FLUOROURACIL
CHEMBL185
|
1962 |
|
|
COLCHICINE
CHEMBL107
|
1961 |
|
|
METHOTREXATE
CHEMBL34259
|
1953 |
|
|
EMETINE
CHEMBL50588
|
— |
Source Header