Assay Detail
Binding
CHEMBL820582
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to prevent phosphorylation of avian c-Src TK
66
Total Activities
66
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL3655) ↗| Type | SINGLE PROTEIN |
| Organism | Gallus gallus |
Publication
Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 66 | 6.87 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45827 | — | — | 1 | 8.13 |
| CHEMBL56983 | — | — | 1 | 8.12 |
| CHEMBL431942 | — | — | 1 | 8.00 |
| CHEMBL293132 | — | — | 1 | 7.92 |
| CHEMBL418111 | — | — | 1 | 7.82 |
| CHEMBL301641 | — | — | 1 | 7.80 |
| CHEMBL418284 | — | — | 1 | 7.80 |
| CHEMBL301483 | — | — | 1 | 7.75 |
| CHEMBL57207 | — | — | 1 | 7.72 |
| CHEMBL417961 | — | — | 1 | 7.70 |
| CHEMBL417208 | — | — | 1 | 7.66 |
| CHEMBL56184 | — | — | 1 | 7.66 |
| CHEMBL292146 | — | — | 1 | 7.66 |
| CHEMBL368189 | — | — | 1 | 7.66 |
| CHEMBL61257 | — | — | 1 | 7.62 |
| CHEMBL60979 | — | — | 1 | 7.54 |
| CHEMBL51485 | — | — | 1 | 7.52 |
| CHEMBL51028 | — | — | 1 | 7.51 |
| CHEMBL57347 | — | — | 1 | 7.50 |
| CHEMBL298679 | — | — | 1 | 7.48 |
| CHEMBL444829 | — | — | 1 | 7.48 |
| CHEMBL293322 | — | — | 1 | 7.44 |
| CHEMBL58652 | — | — | 1 | 7.40 |
| CHEMBL264280 | — | — | 1 | 7.21 |
| CHEMBL299026 | — | — | 1 | 7.14 |
| CHEMBL57022 | — | — | 1 | 7.11 |
| CHEMBL299687 | — | — | 1 | 7.04 |
| CHEMBL301273 | — | — | 1 | 7.03 |
| CHEMBL57803 | — | — | 1 | 7.01 |
| CHEMBL291777 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45827 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL56983 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL431942 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL293132 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL418111 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL301641 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL418284 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL301483 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL57207 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL417961 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL417208 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL56184 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL292146 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL368189 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL61257 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL60979 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL51485 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL51028 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL57347 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL298679 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL444829 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL293322 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL58652 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL264280 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL299026 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL57022 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL299687 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL301273 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL57803 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL291777 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL432708 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL57323 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL294438 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL416501 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL57585 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL443262 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL60690 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL57451 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL298620 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL294711 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL300171 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL58627 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL57947 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL57366 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL58628 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL57229 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL300784 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL56958 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL299270 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL300335 | — | IC50 | = | 860.0 | nM | 6.07 |