Assay Detail
Functional
CHEMBL820595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibition of Tumor necrosis factor, alpha in THP cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | THP |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of the p38alpha MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.72 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344625 | — | — | 1 | 8.05 |
| CHEMBL318810 | — | — | 1 | 8.05 |
| CHEMBL344800 | — | — | 1 | 7.96 |
| CHEMBL143886 | — | — | 1 | 7.80 |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 7.75 |
| CHEMBL104991 | — | — | 1 | 7.72 |
| CHEMBL143134 | — | — | 1 | 7.70 |
| CHEMBL336001 | — | — | 1 | 7.44 |
| CHEMBL143373 | — | — | 1 | 7.38 |
| CHEMBL142115 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344625 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL318810 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL344800 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL143886 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL103667 | DORAMAPIMOD | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL104991 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL143134 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL336001 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL143373 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL142115 | — | EC50 | = | 50.0 | nM | 7.30 |