Assay Detail
Binding
CHEMBL820602
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested in vitro for its inhibitory activity against thromboxane synthase A2 (TXA2)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 3. Pyridinylalkyl-substituted 8-[(arylsulfonyl)amino]octanoic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.72 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65414 | — | — | 1 | 8.70 |
| CHEMBL136904 | — | — | 1 | 8.40 |
| CHEMBL337331 | — | — | 1 | 7.85 |
| CHEMBL136845 | — | — | 1 | 7.70 |
| CHEMBL136905 | — | — | 1 | 7.00 |
| CHEMBL138325 | — | — | 1 | 6.66 |
| CHEMBL136220 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65414 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL136904 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL337331 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL136845 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL136905 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL138325 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL136220 | — | IC50 | > | 500.0 | nM | - |