Assay Detail
Binding
CHEMBL820603
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Thromboxane A2 synthase inhibitory activity was measured from inhibition of thromboxane B2 production in human platelet microsomes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Microsome |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Syntheses and bioactivities of novel carbamates combining platelet activating factor (PAF) receptor antagonist with thromboxane synthase inhibitor (TxSI).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.57 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28196 | ISBOGREL | 2.0 | 1 | 9.05 |
| CHEMBL11662 | OZAGREL | 4.0 | 1 | 7.62 |
| CHEMBL29639 | — | — | 1 | 7.22 |
| CHEMBL28642 | — | — | 1 | 7.21 |
| CHEMBL283814 | — | — | 1 | 7.17 |
| CHEMBL283815 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28196 | ISBOGREL | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL11662 | OZAGREL | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL29639 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL28642 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL283814 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL283815 | — | IC50 | = | 69.0 | nM | 7.16 |