Assay Detail
Binding
CHEMBL820616
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The compound was not tested for inhibition of L1210 Thymidylate synthase due to insolubility
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.79 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422395 | — | — | 1 | 7.30 |
| CHEMBL171480 | — | — | 1 | 6.80 |
| CHEMBL304407 | — | — | 1 | 6.29 |
| CHEMBL62769 | — | — | 1 | 6.21 |
| CHEMBL417562 | — | — | 1 | 6.19 |
| CHEMBL62599 | — | — | 1 | 6.11 |
| CHEMBL302669 | — | — | 1 | 6.00 |
| CHEMBL62675 | — | — | 1 | 5.89 |
| CHEMBL64215 | — | — | 1 | 5.62 |
| CHEMBL62672 | — | — | 1 | 4.96 |
| CHEMBL293442 | — | — | 1 | 4.95 |
| CHEMBL64776 | — | — | 1 | 4.94 |
| CHEMBL433059 | — | — | 1 | 4.02 |
| CHEMBL62419 | — | — | 1 | - |
| CHEMBL61123 | — | — | 1 | - |
| CHEMBL303975 | — | — | 1 | - |
| CHEMBL62697 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422395 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL171480 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL304407 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL62769 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL417562 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL62599 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL302669 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL62675 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL64215 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL62672 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL293442 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL64776 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL433059 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL62419 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL61123 | — | IC50 | - | nM | - | |
| CHEMBL303975 | — | IC50 | - | nM | - | |
| CHEMBL62697 | — | IC50 | >> | 500000.0 | nM | - |