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Assay Detail

CHEMBL820727

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Meleagris gallopavo
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Beta-1 adrenergic receptor (CHEMBL213)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

o-Chlorobenzenesulfonamidic derivatives of (aryloxy)propanolamines as beta-blocking/diuretic agents.
Cecchetti V, Fravolini A, Schiaffella F, Tabarrini O, Bruni G, Segre G.
J Med Chem (1993) 36 : 157 -161
PubMed 8093626 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 7.69 8.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL290313 1 8.85
CHEMBL839 CARTEOLOL 4.0 1 8.72
CHEMBL27 PROPRANOLOL 4.0 1 8.64
CHEMBL289390 1 8.28
CHEMBL38532 1 8.13
CHEMBL43968 1 8.11
CHEMBL40297 1 7.82
CHEMBL446609 1 7.62
CHEMBL41214 1 7.51
CHEMBL40609 1 6.85
CHEMBL43196 1 6.80
CHEMBL40343 1 6.52
CHEMBL44097 1 6.09
CHEMBL41807 1 -
CHEMBL40882 1 -
CHEMBL41062 1 -
CHEMBL40599 1 -
CHEMBL290811 1 -
CHEMBL289592 1 -
CHEMBL41373 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL290313 Ki = 1.4 nM 8.85
CHEMBL839 CARTEOLOL Ki = 1.9 nM 8.72
CHEMBL27 PROPRANOLOL Ki = 2.3 nM 8.64
CHEMBL289390 Ki = 5.2 nM 8.28
CHEMBL38532 Ki = 7.4 nM 8.13
CHEMBL43968 Ki = 7.8 nM 8.11
CHEMBL40297 Ki = 15.0 nM 7.82
CHEMBL446609 Ki = 24.0 nM 7.62
CHEMBL41214 Ki = 31.0 nM 7.51
CHEMBL40609 Ki = 140.0 nM 6.85
CHEMBL43196 Ki = 160.0 nM 6.80
CHEMBL40343 Ki = 300.0 nM 6.52
CHEMBL44097 Ki = 820.0 nM 6.09
CHEMBL41807 Ki - nM -
CHEMBL40882 Ki - nM -
CHEMBL41062 Ki - nM -
CHEMBL40599 Ki - nM -
CHEMBL290811 Ki - nM -
CHEMBL289592 Ki - nM -
CHEMBL41373 Ki - nM -