Assay Detail
Functional
CHEMBL820776
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin polymerization
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 5.74 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 6.34 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.28 |
| CHEMBL279142 | — | — | 1 | 6.24 |
| CHEMBL14120 | — | — | 1 | 6.21 |
| CHEMBL14782 | — | — | 1 | 6.21 |
| CHEMBL10557 | — | — | 1 | 6.20 |
| CHEMBL418350 | — | — | 1 | 6.20 |
| CHEMBL275872 | — | — | 1 | 6.16 |
| CHEMBL14412 | — | — | 1 | 6.13 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.10 |
| CHEMBL14290 | — | — | 1 | 6.08 |
| CHEMBL280099 | — | — | 1 | 6.07 |
| CHEMBL14644 | — | — | 1 | 6.05 |
| CHEMBL418352 | — | — | 1 | 6.00 |
| CHEMBL14691 | — | — | 1 | 5.96 |
| CHEMBL273990 | — | — | 1 | 5.89 |
| CHEMBL276340 | — | — | 1 | 5.85 |
| CHEMBL14633 | — | — | 1 | 5.82 |
| CHEMBL14540 | — | — | 1 | 5.66 |
| CHEMBL14463 | — | — | 1 | 5.64 |
| CHEMBL14337 | — | — | 1 | 5.37 |
| CHEMBL14270 | — | — | 1 | 5.26 |
| CHEMBL14928 | — | — | 1 | 5.25 |
| CHEMBL14536 | — | — | 1 | 4.85 |
| CHEMBL273758 | — | — | 1 | 4.82 |
| CHEMBL14525 | — | — | 1 | 4.75 |
| CHEMBL14087 | — | — | 1 | 4.75 |
| CHEMBL14542 | — | — | 1 | 4.64 |
| CHEMBL279811 | — | — | 1 | - |
| CHEMBL14628 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL279142 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL14120 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL14782 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL10557 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL418350 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL275872 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL14412 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL107 | COLCHICINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL14290 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL280099 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL14644 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL418352 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL14691 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL273990 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL276340 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL14633 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL14540 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL14463 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL14337 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL14270 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL14928 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL14536 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL273758 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL14087 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL14525 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL14542 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL14750 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL14114 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL443474 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL14809 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL14526 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL14944 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL14550 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL15050 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL280101 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL14775 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL14584 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL278474 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL14113 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL14284 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL14544 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL14678 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL15011 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL14323 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL14628 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL279811 | — | IC50 | > | 40000.0 | nM | - |