Assay Detail
Binding
CHEMBL820814
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Inhibitory activity was determined against Escherichia coli beta galactosidase
15
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent glycosidase inhibitors, N-phenyl cyclic isourea derivatives of 5-amino- and 5-amino-1-C-(hydroxymethyl)-cyclopentane-1,2,3,4-tetraols
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.95 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86865 | — | — | 3 | 6.70 |
| CHEMBL87120 | — | — | 3 | 5.11 |
| CHEMBL313375 | — | — | 1 | - |
| CHEMBL86772 | — | — | 3 | - |
| CHEMBL88408 | — | — | 1 | - |
| CHEMBL88413 | — | — | 2 | - |
| CHEMBL314403 | — | — | 1 | - |
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86865 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL86865 | — | IC50 | = | 939.0 | nM | 6.03 |
| CHEMBL87120 | — | IC50 | = | 7780.0 | nM | 5.11 |
| CHEMBL313375 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL86772 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL88408 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL87120 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL88413 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL86865 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL86772 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL87120 | — | IC50 | = | 129000.0 | nM | - |
| CHEMBL314403 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL88413 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL86772 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL307429 | DUVOGLUSTAT | IC50 | > | 300000.0 | nM | - |