Assay Detail
Binding
CHEMBL820843
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Inhibitory activity against CDK4 using recombinant human cyclin D2-CDK4 complex expressed in sf9 cells
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-based generation of a new class of potent Cdk4 inhibitors: new de novo design strategy and library design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.46 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143588 | — | — | 1 | 7.96 |
| CHEMBL344130 | — | — | 1 | 7.77 |
| CHEMBL143580 | — | — | 1 | 7.47 |
| CHEMBL141247 | — | — | 1 | 7.38 |
| CHEMBL140589 | — | — | 1 | 7.00 |
| CHEMBL342863 | — | — | 1 | 6.72 |
| CHEMBL143759 | — | — | 1 | 6.17 |
| CHEMBL143704 | — | — | 1 | 5.62 |
| CHEMBL140583 | — | — | 1 | 5.44 |
| CHEMBL140624 | — | — | 1 | 5.12 |
| CHEMBL141962 | — | — | 1 | 4.85 |
| CHEMBL341824 | PTEROIC ACID | — | 1 | 4.80 |
| CHEMBL139990 | — | — | 1 | 4.64 |
| CHEMBL142641 | — | — | 1 | 4.44 |
| CHEMBL356687 | — | — | 1 | 4.44 |
| CHEMBL143713 | — | — | 1 | 4.40 |
| CHEMBL342899 | — | — | 1 | 4.36 |
| CHEMBL357170 | — | — | 1 | 4.11 |
| CHEMBL139814 | — | — | 1 | 4.05 |
| CHEMBL357461 | — | — | 1 | 4.00 |
| CHEMBL143703 | — | — | 1 | 4.00 |
| CHEMBL585 | TRIAMTERENE | 4.0 | 1 | - |
| CHEMBL140573 | — | — | 1 | - |
| CHEMBL342186 | — | — | 1 | - |
| CHEMBL141987 | — | — | 1 | - |
| CHEMBL140053 | — | — | 1 | - |
| CHEMBL141224 | — | — | 1 | - |
| CHEMBL140574 | — | — | 1 | - |
| CHEMBL142698 | — | — | 1 | - |
| CHEMBL141952 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143588 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL344130 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL143580 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL141247 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL140589 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL342863 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL143759 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL143704 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL140583 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL140624 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL141962 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL341824 | PTEROIC ACID | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL139990 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL142641 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL356687 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL143713 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL342899 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL357170 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL139814 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL357461 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL143703 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL585 | TRIAMTERENE | IC50 | = | 210000.0 | nM | - |
| CHEMBL140573 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL342186 | — | IC50 | = | 340000.0 | nM | - |
| CHEMBL141987 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL140053 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL141224 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL140574 | — | IC50 | = | 220000.0 | nM | - |
| CHEMBL142698 | — | IC50 | = | 450000.0 | nM | - |
| CHEMBL141952 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL139989 | — | IC50 | = | 410000.0 | nM | - |
| CHEMBL342003 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL141159 | — | IC50 | = | 350000.0 | nM | - |