Assay Detail
Binding
CHEMBL820848
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of Vascular endothelial growth factor receptor 3 [VEGFR-3(Flt-4)] expressed in baculovirus
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 3 (CHEMBL1955) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.13 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153843 | — | — | 1 | 7.75 |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 7.30 |
| CHEMBL347537 | — | — | 1 | 7.28 |
| CHEMBL75232 | — | — | 1 | 6.71 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 6.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153843 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL276711 | SEMAXANIB | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL347537 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL75232 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 233.0 | nM | 6.63 |