Assay Detail
Functional
CHEMBL820876
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Vasopressin V2 receptor antagonistic activity in vivo in anesthetized rats
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design of potent and selective linear antagonists of vasopressor (V1-receptor) responses to vasopressin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 14 | 7.35 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408038 | — | — | 1 | 8.11 |
| CHEMBL410838 | — | — | 1 | 7.99 |
| CHEMBL267111 | — | — | 1 | 7.91 |
| CHEMBL2370376 | — | — | 1 | 7.81 |
| CHEMBL406184 | — | — | 1 | 7.81 |
| CHEMBL2370381 | — | — | 1 | 7.70 |
| CHEMBL2370380 | — | — | 1 | 7.66 |
| CHEMBL2373516 | — | — | 1 | 7.36 |
| CHEMBL411320 | — | — | 1 | 7.21 |
| CHEMBL2373374 | — | — | 1 | 7.20 |
| CHEMBL2373423 | — | — | 1 | 7.00 |
| CHEMBL269251 | — | — | 1 | 6.60 |
| CHEMBL2373441 | — | — | 1 | 5.20 |
| CHEMBL2373502 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408038 | — | Kd | = | 7.762 | nM | 8.11 |
| CHEMBL410838 | — | Kd | = | 10.23 | nM | 7.99 |
| CHEMBL267111 | — | Kd | = | 12.3 | nM | 7.91 |
| CHEMBL2370376 | — | Kd | = | 15.49 | nM | 7.81 |
| CHEMBL406184 | — | Kd | = | 15.49 | nM | 7.81 |
| CHEMBL2370381 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL2370380 | — | Kd | = | 21.88 | nM | 7.66 |
| CHEMBL2373516 | — | Kd | = | 43.65 | nM | 7.36 |
| CHEMBL411320 | — | Kd | = | 61.66 | nM | 7.21 |
| CHEMBL2373374 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL2373423 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL269251 | — | Kd | = | 251.19 | nM | 6.60 |
| CHEMBL2373441 | — | Kd | = | 6309.57 | nM | 5.20 |
| CHEMBL2373502 | — | Kd | ~ | 58.88 | nM | - |