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Assay Detail

CHEMBL821074

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Functional
Inhibition of human bladder carcinoma T24 cell proliferation
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type T-24
Confidence 1 — Organism
Curated By Autocuration

Publication

2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors.
Imbach P, Capraro HG, Furet P, Mett H, Meyer T, Zimmermann J.
Bioorg Med Chem Lett (1999) 9 : 91 -96
PubMed 9990463 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.51 6.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL367625 2 6.32
CHEMBL173459 1 6.27
CHEMBL177057 1 6.08
CHEMBL368278 1 5.82
CHEMBL368351 1 5.63
CHEMBL173647 1 5.50
CHEMBL176559 1 5.44
CHEMBL557975 1 5.28
CHEMBL534909 1 5.22
CHEMBL537838 1 5.19
CHEMBL366734 1 5.17
CHEMBL540874 1 5.08
CHEMBL366698 1 5.00
CHEMBL367245 1 4.76

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL367625 IC50 = 480.0 nM 6.32
CHEMBL173459 IC50 = 540.0 nM 6.27
CHEMBL177057 IC50 = 830.0 nM 6.08
CHEMBL367625 IC50 = 1350.0 nM 5.87
CHEMBL368278 IC50 = 1500.0 nM 5.82
CHEMBL368351 IC50 = 2350.0 nM 5.63
CHEMBL173647 IC50 = 3160.0 nM 5.50
CHEMBL176559 IC50 = 3650.0 nM 5.44
CHEMBL557975 IC50 = 5240.0 nM 5.28
CHEMBL534909 IC50 = 6080.0 nM 5.22
CHEMBL537838 IC50 = 6500.0 nM 5.19
CHEMBL366734 IC50 = 6710.0 nM 5.17
CHEMBL540874 IC50 = 8300.0 nM 5.08
CHEMBL366698 IC50 = 9900.0 nM 5.00
CHEMBL367245 IC50 = 17500.0 nM 4.76