Assay Detail
Binding
CHEMBL821239
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The compound was evaluated for the inhibition of dTMP synthetase from Lactobacillus casei
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Inhibition of thymidylate synthetase by 5-alkynyl-2'-deoxyuridylates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.04 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3143871 | — | — | 1 | 7.00 |
| CHEMBL1236538 | — | — | 1 | 6.70 |
| CHEMBL3143870 | — | — | 1 | 5.72 |
| CHEMBL3143873 | — | — | 1 | 5.70 |
| CHEMBL3143872 | — | — | 1 | 5.58 |
| CHEMBL3143869 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3143871 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1236538 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL3143870 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL3143873 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL3143872 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL3143869 | — | Ki | = | 3000.0 | nM | 5.52 |