Assay Detail
Binding
CHEMBL821262
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Tested for binding affinity against thymidylate synthase(TS)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The synthesis and thymidylate synthase inhibitory activity of L-gamma-L-linked dipeptide and L-gamma-amide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.91 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265510 | — | — | 1 | 8.52 |
| CHEMBL6676 | — | — | 1 | 8.00 |
| CHEMBL326727 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265510 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL6676 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL326727 | — | Ki | = | 60.0 | nM | 7.22 |