Assay Detail
Binding
CHEMBL821343
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Inhibition constant for V1a receptor of rat liver membrane
12
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A new series of photoactivatable and iodinatable linear vasopressin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 9.30 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405440 | — | — | 2 | 10.40 |
| CHEMBL412192 | — | — | 2 | 9.92 |
| CHEMBL265048 | — | — | 2 | 9.80 |
| CHEMBL424905 | — | — | 2 | 9.70 |
| CHEMBL441195 | — | — | 2 | 9.51 |
| CHEMBL430301 | — | — | 1 | 7.75 |
| CHEMBL266264 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405440 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL412192 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL265048 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL405440 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL424905 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL265048 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL441195 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL424905 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL412192 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL441195 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL430301 | — | Ki | = | 17.8 | nM | 7.75 |
| CHEMBL266264 | — | Ki | = | 20.0 | nM | 7.70 |