Assay Detail
Binding
CHEMBL821344
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Tested for inhibition constant determined from vasopressin induced inositol phosphates accumulation performed on WRK1 cell line of V1a receptor subtype
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | WRK1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A new series of photoactivatable and iodinatable linear vasopressin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.70 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL424905 | — | — | 1 | 9.96 |
| CHEMBL265048 | — | — | 1 | 9.89 |
| CHEMBL412192 | — | — | 1 | 9.70 |
| CHEMBL441195 | — | — | 1 | 9.62 |
| CHEMBL405440 | — | — | 1 | 9.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL424905 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL265048 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL412192 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL441195 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL405440 | — | Ki | = | 0.46 | nM | 9.34 |