Assay Detail
Binding
CHEMBL821345
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Inhibition of radioligand [3H]AVP binding to V2 receptor in bovine kidney inner medulla membrane
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Enhanced selectivity of oxytocin antagonists containing sarcosine in position 7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 6.97 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373742 | VASOPRESSIN | 4.0 | 1 | 8.82 |
| CHEMBL438387 | — | — | 1 | 7.54 |
| CHEMBL415230 | — | — | 1 | 7.46 |
| CHEMBL265017 | — | — | 1 | 7.01 |
| CHEMBL411420 | — | — | 1 | 6.89 |
| CHEMBL1793955 | — | — | 1 | 6.74 |
| CHEMBL384292 | — | — | 1 | 6.64 |
| CHEMBL265264 | — | — | 1 | 6.62 |
| CHEMBL414582 | — | — | 1 | 6.51 |
| CHEMBL87636 | — | — | 1 | 6.38 |
| CHEMBL330022 | — | — | 1 | 6.09 |
| CHEMBL274397 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373742 | VASOPRESSIN | Kd | = | 1.5 | nM | 8.82 |
| CHEMBL438387 | — | Kd | = | 29.0 | nM | 7.54 |
| CHEMBL415230 | — | Kd | = | 35.0 | nM | 7.46 |
| CHEMBL265017 | — | Kd | = | 98.0 | nM | 7.01 |
| CHEMBL411420 | — | Kd | = | 130.0 | nM | 6.89 |
| CHEMBL1793955 | — | Kd | = | 182.0 | nM | 6.74 |
| CHEMBL384292 | — | Kd | = | 230.0 | nM | 6.64 |
| CHEMBL265264 | — | Kd | = | 240.0 | nM | 6.62 |
| CHEMBL414582 | — | Kd | = | 311.0 | nM | 6.51 |
| CHEMBL87636 | — | Kd | = | 421.0 | nM | 6.38 |
| CHEMBL330022 | — | Kd | = | 811.0 | nM | 6.09 |
| CHEMBL274397 | — | Kd | = | 300000.0 | nM | - |