Assay Detail
Binding
CHEMBL821423
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Concentration required to inhibit 50% relaxation of 250 ng of SV40 DNA obtained with 0.5 I.U topoisomerase I at 37 degrees C for 30 min
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and cytotoxic activity of alkylidene- and alkyl-substituted camptothecins
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.09 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274070 | 9-AMINOCAMPTOTHECIN | 2.0 | 1 | 5.75 |
| CHEMBL413917 | — | — | 1 | 5.50 |
| CHEMBL352800 | — | — | 1 | 5.38 |
| CHEMBL355285 | — | — | 1 | 5.17 |
| CHEMBL168822 | — | — | 1 | 4.95 |
| CHEMBL168975 | — | — | 1 | 4.50 |
| CHEMBL353588 | — | — | 1 | 4.38 |
| CHEMBL354671 | — | — | 1 | - |
| CHEMBL168505 | — | — | 1 | - |
| CHEMBL352709 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274070 | 9-AMINOCAMPTOTHECIN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL413917 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL352800 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL355285 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL168822 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL168975 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL353588 | — | IC50 | = | 41800.0 | nM | 4.38 |
| CHEMBL354671 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL168505 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL352709 | — | IC50 | > | 100000.0 | nM | - |