Assay Detail
Functional
CHEMBL821542
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Ability to inhibit the proliferation of c-Src transformed rat fibroblasts growing in suspension
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.46 | 7.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128705 | — | — | 1 | 7.15 |
| CHEMBL129209 | — | — | 1 | 7.00 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 7.00 |
| CHEMBL130529 | — | — | 1 | 6.89 |
| CHEMBL131725 | — | — | 1 | 6.85 |
| CHEMBL423696 | — | — | 1 | 6.82 |
| CHEMBL334364 | — | — | 1 | 6.82 |
| CHEMBL128706 | — | — | 1 | 6.82 |
| CHEMBL129143 | — | — | 1 | 6.80 |
| CHEMBL131245 | — | — | 1 | 6.80 |
| CHEMBL339893 | — | — | 1 | 6.72 |
| CHEMBL340914 | — | — | 1 | 6.66 |
| CHEMBL130242 | — | — | 1 | 6.50 |
| CHEMBL128612 | — | — | 1 | 6.48 |
| CHEMBL128326 | — | — | 1 | 6.46 |
| CHEMBL338194 | — | — | 1 | 6.21 |
| CHEMBL129968 | — | — | 1 | 6.19 |
| CHEMBL424262 | — | — | 1 | 6.08 |
| CHEMBL129972 | — | — | 1 | 6.04 |
| CHEMBL440160 | — | — | 1 | 6.03 |
| CHEMBL340350 | — | — | 1 | 5.92 |
| CHEMBL128241 | — | — | 1 | 5.92 |
| CHEMBL340944 | — | — | 1 | 5.85 |
| CHEMBL128158 | — | — | 1 | 5.77 |
| CHEMBL129776 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128705 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL129209 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL130529 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL131725 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL423696 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL334364 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL128706 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL129143 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL131245 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL339893 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL340914 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL130242 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL128612 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL128326 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL338194 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL129968 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL424262 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL129972 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL440160 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL340350 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL128241 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL340944 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL128158 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL129776 | — | IC50 | = | 1900.0 | nM | 5.72 |