Assay Detail
Binding
CHEMBL821550
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cAMP PDE and cGMP-inhibited PDE from rabbit aorta
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Phosphodiesterase; PDE3 & PDE4 (CHEMBL2095153) ↗| Type | SELECTIVITY GROUP |
| Organism | Homo sapiens |
Publication
Synthesis and phosphodiesterase activity of carboxylic acid mimetics of cyclic guanosine 3',5'-monophosphate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.84 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280360 | — | — | 1 | 6.92 |
| CHEMBL19984 | DEOXYGRISEOLIC ACID | — | 1 | 6.80 |
| CHEMBL416178 | GRISEOLIC ACID | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280360 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL19984 | DEOXYGRISEOLIC ACID | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL416178 | GRISEOLIC ACID | IC50 | = | 160.0 | nM | 6.80 |