Assay Detail
Functional
CHEMBL821617
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Evaluated for inhibition of proliferation of human coronary artery endothelial cells (ECs), induced by 5 % FBS.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Endothelial cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.17 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346669 | — | — | 1 | 5.54 |
| CHEMBL153530 | — | — | 1 | 5.42 |
| CHEMBL436463 | — | — | 1 | 5.39 |
| CHEMBL347756 | — | — | 1 | 5.34 |
| CHEMBL435483 | — | — | 1 | 5.33 |
| CHEMBL345753 | — | — | 1 | 5.28 |
| CHEMBL153625 | — | — | 1 | 5.22 |
| CHEMBL359343 | — | — | 1 | 5.21 |
| CHEMBL358608 | — | — | 1 | 5.14 |
| CHEMBL150536 | — | — | 1 | 5.02 |
| CHEMBL415324 | TRANILAST | 3.0 | 1 | 4.72 |
| CHEMBL359070 | — | — | 1 | 4.46 |
| CHEMBL153351 | — | — | 1 | - |
| CHEMBL345497 | — | — | 1 | - |
| CHEMBL150454 | — | — | 1 | - |
| CHEMBL152760 | — | — | 1 | - |
| CHEMBL153627 | — | — | 1 | - |
| CHEMBL153240 | — | — | 1 | - |
| CHEMBL153033 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346669 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL153530 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL436463 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL347756 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL435483 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL345753 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL153625 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL359343 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL358608 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL150536 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL415324 | TRANILAST | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL359070 | — | IC50 | = | 34500.0 | nM | 4.46 |
| CHEMBL153351 | — | IC50 | < | 2000.0 | nM | - |
| CHEMBL345497 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL150454 | — | IC50 | = | - | nM | - |
| CHEMBL152760 | — | IC50 | = | - | nM | - |
| CHEMBL153627 | — | IC50 | = | - | nM | - |
| CHEMBL153240 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL153033 | — | IC50 | < | 2000.0 | nM | - |