Assay Detail
Functional
CHEMBL821648
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Compound was tested for growth inhibition against human YAPC cell lines
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | YAPC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis, X-ray crystal structures, stabilities, and in vitro cytotoxic activities of new heteroarylacrylonitriles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.11 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440896 | — | — | 1 | 6.80 |
| CHEMBL323906 | — | — | 1 | 6.50 |
| CHEMBL331583 | — | — | 1 | 6.44 |
| CHEMBL430890 | — | — | 1 | 6.39 |
| CHEMBL116696 | — | — | 1 | 6.35 |
| CHEMBL117966 | — | — | 1 | 6.24 |
| CHEMBL117076 | — | — | 1 | 6.07 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.88 |
| CHEMBL113815 | — | — | 1 | 5.85 |
| CHEMBL117195 | — | — | 1 | 5.46 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440896 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL323906 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL331583 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL430890 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL116696 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL117966 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL117076 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL113815 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL117195 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 6030.0 | nM | 5.22 |