Assay Detail

CHEMBL821683

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Functional

Induced current in Xenopus laevis oocytes expressing cloned mKCNQ2 channels

ChEMBL ↗

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Target

Potassium voltage-gated channel subfamily KQT member 2 (CHEMBL2985) ↗

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Potassium voltage-gated channel subfamily KQT member 2 (CHEMBL2985) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Potassium voltage-gated channel subfamily KQT member 2

CHEMBL2985

Anchored from Assay target.

Protein identity Potassium voltage-gated channel subfamily KQT member 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Cell Type	Oocyte
Confidence	9 — Direct single protein target
Curated By	Expert

Target

Potassium voltage-gated channel subfamily KQT member 2 (CHEMBL2985) ↗

Type	SINGLE PROTEIN
Organism	Mus musculus

Publication

(S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine.

Wu YJ, Boissard CG, Greco C, Gribkoff VK, Harden DG, He H, L'Heureux A, Kang SH, Kinney GG, Knox RJ, Natale J, Newton AE, Lehtinen-Oboma S, Sinz MW, Sivarao DV, Starrett JE, Sun LQ, Tertyshnikova S, Thompson MW, Weaver D, Wong HS, Zhang L, Dworetzky SI.
J Med Chem (2003) 46 : 3197 -3200
PubMed 12852750 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	5.22	5.22

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL317935	—	—	1	5.22

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL317935	—	EC50	=	6000.0	nM	5.22