Assay Detail
Binding
CHEMBL821744
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Binding affinity against oxytocin receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A study of the relationship between biological activity and prolyl amide isomer geometry in oxytocin using 5-tert-butylproline to augment the Cys(6)-Pro(7) amide cis-isomer population.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.80 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435716 | DEMOXYTOCIN | 2.0 | 1 | 8.49 |
| CHEMBL2372252 | — | — | 1 | 6.77 |
| CHEMBL2372253 | — | — | 1 | 6.62 |
| CHEMBL2372251 | — | — | 1 | 6.27 |
| CHEMBL429161 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435716 | DEMOXYTOCIN | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL2372252 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL2372253 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL2372251 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL429161 | — | Ki | = | 1430.0 | nM | 5.84 |