Assay Detail
Functional
CHEMBL821851
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Agonistic activity was determined in a pigment aggregation model using cultured melanophores isolated from the neural crest of Xenopus laevis embryos
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | frog |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Mapping the melatonin receptor. 2. synthesis and biological activity of indole derived melatonin analogues with restricted conformations of the C-3 amidoethane side chain
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.80 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290895 | — | — | 1 | 8.60 |
| CHEMBL290271 | — | — | 1 | 5.00 |
| CHEMBL41148 | — | — | 1 | - |
| CHEMBL291120 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290895 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL290271 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL41148 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL291120 | — | EC50 | < | 1000.0 | nM | - |