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Assay Detail

CHEMBL821853

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Functional
Effective concentration required to produce 50% of the maximal pigment aggregation in Xenopus laevis dermal melanophore cell line
ChEMBL ↗
43
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism frog
Cell Type Melanophore
Confidence 1 — Organism
Curated By Expert

Target

Melanophore (CHEMBL614313) ↗
Type CELL-LINE
Organism Xenopus laevis

Publication

Mapping the melatonin receptor. 5. Melatonin agonists and antagonists derived from tetrahydrocyclopent[b]indoles, tetrahydrocarbazoles and hexahydrocyclohept[b]indoles.
Davies DJ, Garratt PJ, Tocher DA, Vonhoff S, Davies J, Teh MT, Sugden D.
J Med Chem (1998) 41 : 451 -467
PubMed 9484496 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 43 6.99 9.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL45 MELATONIN 4.0 1 9.64
CHEMBL53824 — — 3 9.52
CHEMBL127826 — — 1 9.51
CHEMBL142343 — — 1 9.36
CHEMBL359451 — — 1 8.68
CHEMBL143125 — — 3 8.47
CHEMBL141146 — — 1 8.28
CHEMBL287776 — — 1 8.15
CHEMBL290271 — — 1 7.60
CHEMBL38520 — — 1 7.50
CHEMBL41105 — — 1 7.50
CHEMBL417343 — — 1 7.50
CHEMBL342723 — — 2 7.04
CHEMBL142567 — — 1 6.97
CHEMBL424297 — — 1 6.92
CHEMBL143074 — — 1 6.89
CHEMBL345090 — — 1 6.88
CHEMBL342335 — — 1 6.86
CHEMBL335352 — — 1 6.85
CHEMBL127827 — — 2 6.72
CHEMBL288206 — — 1 6.71
CHEMBL139873 — — 1 6.59
CHEMBL143677 — — 1 6.52
CHEMBL141944 — — 1 6.47
CHEMBL358629 — — 1 6.37
CHEMBL143547 — — 1 6.33
CHEMBL140728 — — 1 6.13
CHEMBL127036 — — 1 6.06
CHEMBL358401 — — 1 6.01
CHEMBL143543 — — 1 5.84

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL45 MELATONIN EC50 = 0.23 nM 9.64
CHEMBL53824 — EC50 = 0.3 nM 9.52
CHEMBL127826 — EC50 = 0.31 nM 9.51
CHEMBL142343 — EC50 = 0.44 nM 9.36
CHEMBL53824 — EC50 = 0.7 nM 9.15
CHEMBL359451 — EC50 = 2.1 nM 8.68
CHEMBL143125 — EC50 = 3.4 nM 8.47
CHEMBL141146 — EC50 = 5.2 nM 8.28
CHEMBL287776 — EC50 = 7.0 nM 8.15
CHEMBL53824 — EC50 = 14.8 nM 7.83
CHEMBL290271 — EC50 = 25.0 nM 7.60
CHEMBL41105 — EC50 = 32.0 nM 7.50
CHEMBL417343 — EC50 = 32.0 nM 7.50
CHEMBL38520 — EC50 = 32.0 nM 7.50
CHEMBL342723 — EC50 = 91.0 nM 7.04
CHEMBL142567 — EC50 = 108.0 nM 6.97
CHEMBL342723 — EC50 = 118.0 nM 6.93
CHEMBL424297 — EC50 = 119.0 nM 6.92
CHEMBL143074 — EC50 = 128.0 nM 6.89
CHEMBL345090 — EC50 = 132.0 nM 6.88
CHEMBL342335 — EC50 = 139.0 nM 6.86
CHEMBL335352 — EC50 = 140.0 nM 6.85
CHEMBL127827 — EC50 = 189.0 nM 6.72
CHEMBL288206 — EC50 = 195.0 nM 6.71
CHEMBL139873 — EC50 = 258.0 nM 6.59
CHEMBL143677 — EC50 = 305.0 nM 6.52
CHEMBL141944 — EC50 = 335.0 nM 6.47
CHEMBL143125 — EC50 = 408.0 nM 6.39
CHEMBL358629 — EC50 = 423.0 nM 6.37
CHEMBL143547 — EC50 = 470.0 nM 6.33
CHEMBL127827 — EC50 = 599.0 nM 6.22
CHEMBL140728 — EC50 = 733.0 nM 6.13
CHEMBL143125 — EC50 = 789.0 nM 6.10
CHEMBL127036 — EC50 = 862.0 nM 6.06
CHEMBL358401 — EC50 = 966.0 nM 6.01
CHEMBL143543 — EC50 = 1450.0 nM 5.84
CHEMBL141011 — EC50 = 1511.0 nM 5.82
CHEMBL344521 — EC50 = 2030.0 nM 5.69
CHEMBL142382 — EC50 = 2630.0 nM 5.58
CHEMBL41148 — EC50 = 3270.0 nM 5.49
CHEMBL343360 — EC50 = 4045.0 nM 5.39
CHEMBL140785 — EC50 = 6360.0 nM 5.20
CHEMBL38720 — EC50 = 12600.0 nM 4.90