Assay Detail
Binding
CHEMBL822104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of saturable binding of [3H]prazosin to alpha1-site in rat cerebral cortical membranes.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Indoline analogues of idazoxan: potent alpha 2-antagonists and alpha 1-agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.42 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL172132 | — | — | 1 | 8.72 |
| CHEMBL36616 | — | — | 1 | 8.43 |
| CHEMBL38788 | — | — | 1 | 8.43 |
| CHEMBL537841 | — | — | 1 | 8.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL172132 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL36616 | — | Ki | = | 3.72 | nM | 8.43 |
| CHEMBL38788 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL537841 | — | Ki | = | 8.4 | nM | 8.08 |