Assay Detail
Binding
CHEMBL822216
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcine TNF-alpha converting enzyme (pTACE).
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3332) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.15 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91636 | — | — | 1 | 8.38 |
| CHEMBL88520 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91636 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL88520 | — | Ki | = | 12.0 | nM | 7.92 |