Assay Detail
Functional
CHEMBL822272
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Evaluated for the anti-VZV activity, the concentration of compounds in uM required to reduce VZV OKA plaque formation after 5 days in HEL cell cultures compared to untreated controls.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.66 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147871 | — | — | 1 | 8.10 |
| CHEMBL343656 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147871 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL343656 | — | EC50 | = | 60.0 | nM | 7.22 |