Assay Detail
Functional
CHEMBL822312
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for agonistic activity against mGluR1 alpha metabotropic receptor subtype in rat cortical slice model
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Metabotropic glutamate receptor 1 (CHEMBL4477) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacology of N-alkylated derivatives of the excitotoxin ibotenic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.37 | 4.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284895 | — | — | 1 | 4.37 |
| CHEMBL287785 | — | — | 1 | - |
| CHEMBL280585 | — | — | 1 | - |
| CHEMBL41352 | — | — | 1 | - |
| CHEMBL287737 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284895 | — | EC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL287785 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL280585 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL41352 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL287737 | — | EC50 | > | 1000000.0 | nM | - |