Assay Detail
Binding
CHEMBL822437
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p60 c-Src tyrosine kinase enzyme activity in liquid-phase tyrosine phosphorylation assay at 830 ng/mL
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
7-Pyrrolidinyl- and 7-piperidinyl-5-aryl-pyrrolo[2,3-d]pyrimidines--potent inhibitors of the tyrosine kinase c-Src.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 7.32 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263528 | — | — | 1 | 9.00 |
| CHEMBL169780 | — | — | 1 | 9.00 |
| CHEMBL169920 | — | — | 1 | 8.52 |
| CHEMBL355019 | — | — | 1 | 8.52 |
| CHEMBL408683 | — | — | 1 | 8.40 |
| CHEMBL169939 | — | — | 1 | 8.30 |
| CHEMBL168921 | — | — | 1 | 8.30 |
| CHEMBL171545 | — | — | 1 | 8.22 |
| CHEMBL168661 | — | — | 1 | 8.22 |
| CHEMBL422565 | — | — | 1 | 8.10 |
| CHEMBL352829 | — | — | 1 | 7.82 |
| CHEMBL172514 | — | — | 1 | 7.82 |
| CHEMBL169064 | — | — | 1 | 7.66 |
| CHEMBL169043 | — | — | 1 | 7.62 |
| CHEMBL169200 | — | — | 1 | 7.57 |
| CHEMBL352666 | — | — | 1 | 7.46 |
| CHEMBL354033 | — | — | 1 | 7.43 |
| CHEMBL355322 | — | — | 1 | 7.42 |
| CHEMBL274732 | — | — | 1 | 7.33 |
| CHEMBL355891 | — | — | 1 | 7.30 |
| CHEMBL168462 | — | — | 1 | 7.30 |
| CHEMBL169519 | — | — | 1 | 7.28 |
| CHEMBL355269 | — | — | 1 | 7.17 |
| CHEMBL169065 | — | — | 1 | 7.08 |
| CHEMBL172574 | — | — | 1 | 7.02 |
| CHEMBL170726 | — | — | 1 | 7.00 |
| CHEMBL353630 | — | — | 1 | 6.89 |
| CHEMBL168560 | — | — | 1 | 6.89 |
| CHEMBL353823 | — | — | 1 | 6.75 |
| CHEMBL168829 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263528 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL169780 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL355019 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL169920 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL408683 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL169939 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL168921 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL171545 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL168661 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL422565 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL172514 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL352829 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL169064 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL169043 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL169200 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL352666 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL354033 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL355322 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL274732 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL168462 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL355891 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL169519 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL355269 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL169065 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL172574 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL170726 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL353630 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL168560 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL353823 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL168829 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL168656 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL367933 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL353456 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL352652 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL434105 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL352619 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL169202 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL352510 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL167537 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL170004 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL262276 | — | IC50 | < | 1.0 | nM | - |