Assay Detail
Functional
CHEMBL822467
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Antiviral activity against YS strain of thymidine kinase positive(TK+) Varicella-Zoster Virus (VZV)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.47 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146350 | — | — | 1 | 8.15 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 8.10 |
| CHEMBL344107 | — | — | 1 | 6.92 |
| CHEMBL413063 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146350 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL344107 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL413063 | — | EC50 | = | 200.0 | nM | 6.70 |