Assay Detail
Binding
CHEMBL822530
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of saturable binding of [3H]idazoxan to alpha2-site in rat cerebral cortical membranes.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Indoline analogues of idazoxan: potent alpha 2-antagonists and alpha 1-agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.18 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL556758 | — | — | 1 | 9.80 |
| CHEMBL36616 | — | — | 1 | 9.62 |
| CHEMBL172132 | — | — | 1 | 9.38 |
| CHEMBL38829 | — | — | 1 | 9.16 |
| CHEMBL38788 | — | — | 1 | 9.02 |
| CHEMBL289153 | — | — | 1 | 8.73 |
| CHEMBL537841 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL556758 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL36616 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL172132 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL38829 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL38788 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL289153 | — | Ki | = | 1.87 | nM | 8.73 |
| CHEMBL537841 | — | Ki | = | 3.0 | nM | 8.52 |