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Assay Detail

CHEMBL822646

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]PDBU from protein kinase C-alpha
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Protein kinase C alpha type (CHEMBL299)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis of ingenol analogs wth affinity for protein kinase C
Winkler JD, Hong B, Bahador A, Kazanietz MG, Blumberg PM
Bioorg Med Chem Lett (1993) 3 : 577 -580
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 8.32 9.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL46094 1 9.85
CHEMBL156719 1 6.78

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL46094 Ki = 0.14 nM 9.85
CHEMBL156719 Ki = 165.0 nM 6.78