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Assay Detail

CHEMBL822796

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding potency for nAChR subtype Alpha-1-beta-1-delta gamma(torpedo)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Torpedo
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Acetylcholine receptor (CHEMBL2096975)
Type PROTEIN COMPLEX
Organism Torpedo californica

Publication

Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
Holladay MW, Dart MJ, Lynch JK.
J Med Chem (1997) 40 : 4169 -4194
PubMed 9435889 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 3 7.54 8.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL6623 EPIBATIDINE 1 8.57
CHEMBL335712 1 6.50
CHEMBL274525 ABT-418 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL6623 EPIBATIDINE Ki = 2.7 nM 8.57
CHEMBL335712 Ki = 314.0 nM 6.50
CHEMBL274525 ABT-418 Ki > 10000.0 nM -