Assay Detail
Binding
CHEMBL822798
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its ability to displace [125 I]alpha-bungarotoxin (alpha-BgT) from torpedo alpha1-beta1-gamma1 electroplax
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Torpedo |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Acetylcholine receptor subunit alpha (CHEMBL3097) ↗| Type | SINGLE PROTEIN |
| Organism | Torpedo californica |
Publication
Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.63 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL262769 | — | — | 1 | 6.42 |
| CHEMBL430497 | TEBANICLINE | 2.0 | 2 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL262769 | — | Ki | = | 384.0 | nM | 6.42 |
| CHEMBL430497 | TEBANICLINE | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL430497 | TEBANICLINE | Ki | = | 10000.0 | nM | 5.00 |