Assay Detail
Binding
CHEMBL822802
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-src tyrosine kinase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.01 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301483 | — | — | 1 | 7.64 |
| CHEMBL57347 | — | — | 1 | 7.51 |
| CHEMBL45827 | — | — | 1 | 7.36 |
| CHEMBL299026 | — | — | 1 | 7.14 |
| CHEMBL432738 | — | — | 1 | 7.11 |
| CHEMBL57323 | — | — | 1 | 6.96 |
| CHEMBL57366 | — | — | 1 | 6.66 |
| CHEMBL75188 | — | — | 1 | 5.66 |
| CHEMBL76599 | — | — | 1 | - |
| CHEMBL299763 | — | — | 1 | - |
| CHEMBL56236 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301483 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL57347 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL45827 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL299026 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL432738 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL57323 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL57366 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL75188 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL76599 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL299763 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL56236 | — | IC50 | > | 50000.0 | nM | - |