Assay Detail
Binding
CHEMBL822822
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its ability to inhibit specific binding of [3H]clonidine to alpha-2-adrenoceptor in rat brain
2
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Two stereoisomeric imidazoline derivatives: synthesis and optical and alpha 2-adrenoceptor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.91 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1788132 | LOFEXIDINE HYDROCHLORIDE | 4.0 | 2 | 8.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1788132 | LOFEXIDINE HYDROCHLORIDE | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL1788132 | LOFEXIDINE HYDROCHLORIDE | IC50 | = | 43.0 | nM | 7.37 |