Assay Detail
Binding
CHEMBL822877
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Binding affinity of the receptor corticotropin releasing factor receptor with peptidic agonists
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Corticotropin releasing factor (CRF) receptor modulators: progress and opportunities for new therapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.46 | 8.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2373995 | — | — | 1 | 8.97 |
| CHEMBL263451 | — | — | 1 | 8.70 |
| CHEMBL427807 | — | — | 1 | 8.43 |
| CHEMBL2372650 | — | — | 1 | 8.35 |
| CHEMBL1077301 | — | — | 1 | 8.14 |
| CHEMBL429560 | — | — | 1 | 8.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2373995 | — | Ki | = | 1.07 | nM | 8.97 |
| CHEMBL263451 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL427807 | — | Ki | = | 3.76 | nM | 8.43 |
| CHEMBL2372650 | — | Ki | = | 4.43 | nM | 8.35 |
| CHEMBL1077301 | — | Ki | = | 7.16 | nM | 8.14 |
| CHEMBL429560 | — | Ki | = | 7.3 | nM | 8.14 |