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Assay Detail

CHEMBL822907

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Binding
In vitro inhibitory concentration against Xanthine oxidase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Xanthine dehydrogenase/oxidase (CHEMBL3649)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors.
Ishibuchi S, Morimoto H, Oe T, Ikebe T, Inoue H, Fukunari A, Kamezawa M, Yamada I, Naka Y.
Bioorg Med Chem Lett (2001) 11 : 879 -882
PubMed 11294382 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.76 8.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL169526 1 8.24
CHEMBL170303 1 8.15
CHEMBL440197 1 7.82
CHEMBL171584 1 7.68
CHEMBL171819 1 7.48
CHEMBL354749 1 7.37
CHEMBL1467 ALLOPURINOL 4.0 1 6.58
CHEMBL435703 1 6.34
CHEMBL172687 1 6.16
CHEMBL354997 1 5.82
CHEMBL169728 1 5.48
CHEMBL172682 1 5.44
CHEMBL169420 1 5.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL169526 IC50 = 5.8 nM 8.24
CHEMBL170303 IC50 = 7.1 nM 8.15
CHEMBL440197 IC50 = 15.0 nM 7.82
CHEMBL171584 IC50 = 21.0 nM 7.68
CHEMBL171819 IC50 = 33.0 nM 7.48
CHEMBL354749 IC50 = 43.0 nM 7.37
CHEMBL1467 ALLOPURINOL IC50 = 260.0 nM 6.58
CHEMBL435703 IC50 = 460.0 nM 6.34
CHEMBL172687 IC50 = 700.0 nM 6.16
CHEMBL354997 IC50 = 1500.0 nM 5.82
CHEMBL169728 IC50 = 3300.0 nM 5.48
CHEMBL172682 IC50 = 3600.0 nM 5.44
CHEMBL169420 IC50 = 4700.0 nM 5.33