Assay Detail
Binding
CHEMBL823202
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Compound was evaluated for binding affinity against [3H]- bremazocine labeled kappa2 opioid receptor in guinea-pig brain homogenate.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
6N-Cinnamoyl--naltrexamine and its p-nitro derivative. High efficacy -opioid agonists with weak antagonist actions
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.34 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473362 | — | — | 1 | 7.89 |
| CHEMBL417535 | — | — | 1 | 7.52 |
| CHEMBL296693 | — | — | 1 | 7.32 |
| CHEMBL473136 | — | — | 1 | 7.18 |
| CHEMBL297756 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473362 | — | Ki | = | 12.8 | nM | 7.89 |
| CHEMBL417535 | — | Ki | = | 30.5 | nM | 7.52 |
| CHEMBL296693 | — | Ki | = | 48.3 | nM | 7.32 |
| CHEMBL473136 | — | Ki | = | 66.5 | nM | 7.18 |
| CHEMBL297756 | — | Ki | = | 171.4 | nM | 6.77 |