Assay Detail
Binding
CHEMBL823219
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Inhibition of p56 lck tyrosine kinase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Arylamides of hydroxylated isoquinolines as protein-tyrosine kinase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.68 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48384 | — | — | 1 | 6.30 |
| CHEMBL48436 | — | — | 1 | 6.00 |
| CHEMBL48650 | — | — | 1 | 6.00 |
| CHEMBL49350 | — | — | 1 | 4.40 |
| CHEMBL295939 | — | — | 1 | - |
| CHEMBL50415 | — | — | 1 | - |
| CHEMBL296582 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48384 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL48436 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL48650 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL49350 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL295939 | — | IC50 | = | 1900000.0 | nM | - |
| CHEMBL50415 | — | IC50 | = | 600000.0 | nM | - |
| CHEMBL296582 | — | IC50 | > | 1000000.0 | nM | - |