Compound Detail
CHEMBL48384
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Basic Information
| ChEMBL ID | CHEMBL48384 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FIBTUUYKTWYAAG-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
204.2
MW (Da)
0.74
ALogP
4
HBA
3
HBD
96.4
PSA (Ų)
0.60
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase Lck CHEMBL258 | IC50 | 6.3 | 6.3 | 500.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase Lck | IC50 | = | 500.0 | nM | 6.3 | Inhibition of Lck kinase | 8027985 |
| Tyrosine-protein kinase Lck | IC50 | = | 500.0 | nM | 6.3 | Ability to inhibit autophosphorylation of immunopurified p56Ick | 8474097 |
| Tyrosine-protein kinase Lck | IC50 | = | 500.0 | nM | 6.3 | Inhibition of p56 lck tyrosine kinase | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8027985 | 10.1021/jm00039a016 | Tyrosine-protein kinase Lck | 1 |
| 8474097 | 10.1021/jm00056a001 | Tyrosine-protein kinase Lck | 1 |
| - | 10.1016/S0960-894X(00)80473-4 | Epidermal growth factor receptor | 1 |
| - | 10.1016/S0960-894X(00)80473-4 | Tyrosine-protein kinase Lck | 1 |
Data from ChEMBL 36 via Core Engine