Assay Detail
Binding
CHEMBL823225
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Dissociation constant for binding to SH2 domain of p56 lck tyrosine kinase
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Acquisition of high-affinity, SH2-targeted ligands via a spatially focused library.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 6.44 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12253 | — | — | 1 | 7.46 |
| CHEMBL165399 | — | — | 1 | 6.66 |
| CHEMBL349371 | — | — | 1 | 6.62 |
| CHEMBL164585 | — | — | 1 | 6.58 |
| CHEMBL8682 | — | — | 1 | 6.54 |
| CHEMBL539 | ACETIC ACID | 4.0 | 2 | 6.19 |
| CHEMBL268282 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12253 | — | Kd | = | 35.0 | nM | 7.46 |
| CHEMBL165399 | — | Kd | = | 220.0 | nM | 6.66 |
| CHEMBL349371 | — | Kd | = | 240.0 | nM | 6.62 |
| CHEMBL164585 | — | Kd | = | 260.0 | nM | 6.58 |
| CHEMBL8682 | — | Kd | = | 290.0 | nM | 6.54 |
| CHEMBL539 | ACETIC ACID | Kd | = | 640.0 | nM | 6.19 |
| CHEMBL539 | ACETIC ACID | Kd | = | 1300.0 | nM | 5.89 |
| CHEMBL268282 | — | Kd | = | 2500.0 | nM | 5.60 |